Background: Duodenal gastrointestinal stromal tumors (DGIST) are rare, and data on their management is limited.\nWe here report the clinicopathological characteristics, different surgical treatments, and long-term prognosis of DGIST.\nMethods: Data of 74 consecutive patients with DGIST in a single institution from June 2000 to June 2014 were\nretrospectively analyzed. The overall survival (OS) and recurrence/metastasis-free survival rates of 74 cases were\ncalculated using Kaplanââ?¬â??Meier method.\nResults: Out of 74 cases, 42 cases were female (56.76 %) and 32 cases (43.24 %) were male. Approximately 22.97, 47.30,\n16.22, and 13.51 % of the tumors originated in the first to fourth portion of the duodenum, respectively,\nwith a tumor size of 5.08 Ã?± 2.90 cm. Patients presented with gastrointestinal bleeding (n = 37, 50.00 %),\nabdominal pain (n = 25, 33.78 %), mass (n = 5, 6.76 %), and others (n = 7, 9.76 %). A total of 18 patients\n(24.3 %) underwent wedge resection (WR); 39 patients (52.7 %) underwent segmental resection (SR); and 17\ncases (23 %) underwent pancreaticoduodenectomy (PD). The median follow-up was 56 months (1ââ?¬â??159\nmonths); 19 patients (25.68 %) experienced tumor recurrence or metastasis, and 14 cases (18.92 %) died.\nThe 1-, 3-, and 5-year recurrence/metastasis-free survival rates were 93.9, 73.7, and 69 %, respectively. The 1-, 3-\nand 5-year OS were 100, 92.5, and 86 %, respectively. The recurrence/metastasis-free survival rate in the PD group\nwithin 5 years was lower than that in the WR group (P = 0.047), but was not different from that in the SR group\n(P = 0.060). No statistically significant difference was found among the three operation types (P = 0.294).\nConclusions: DGIST patients have favorable prognosis after complete tumor removal, and surgical procedures\nshould be determined by the DGIST tumor location and size.
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